fyn is a redox sensor involved solar light

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fyn is a redox sensor involved solar light

Fyn Is a Redox Sensor Involved in Solar Ultraviolet Light ...

We use an experimental system of solar simulated light (SSL) to mimic solar UV and we demonstrate that Fyn is a primary redox sensor involved in SSL-induced signal transduction. Reactive oxygen species (ROS) generated by SSL exposure directly oxidize Cys488 of Fyn, resulting in increased Fyn kinase activity. Fyn oxidation was increased in mouse skin after SSL exposure and Fyn-knockout mice formed larger and more tumors compared with Fyn …

Fyn is a redox sensor involved in solar ultraviolet light ...

We use an experimental system of solar simulated light (SSL) to mimic solar UV and we demonstrate that Fyn is a primary redox sensor involved in SSL-induced signal transduction. Reactive oxygen ...

Fyn is a redox sensor involved in solar ultraviolet light ...

We use an experimental system of solar simulated light (SSL) to mimic solar UV and we demonstrate that Fyn is a primary redox sensor involved in SSL-induced signal transduction. Reactive oxygen species (ROS) generated by SSL exposure directly oxidize Cys488 of Fyn, resulting in increased Fyn kinase activity. Fyn oxidation was increased in mouse skin after SSL exposure and Fyn-knockout mice ...

Fyn is a redox sensor involved in solar ultraviolet light ...

Fyn is a redox sensor involved in solar ultraviolet light-induced signal transduction in skin carcinogenesis

Fyn is a redox sensor involved in solar ultraviolet light ...

21.12.2015· We use an experimental system of solar simulated light (SSL) to mimic solar UV and we demonstrate that Fyn is a primary redox sensor involved in SSL-induced signal transduction. Reactive oxygen species (ROS) generated by SSL exposure directly oxidize Cys488 of Fyn, resulting in increased Fyn kinase activity. Fyn oxidation was increased in mouse skin after SSL exposure and Fyn-knockout mice formed larger and more tumors compared with Fyn …

Fyn - Saito - 2010 - Cancer - Wiley Online Library

11.02.2010· J-E Kim, E Roh, M H Lee, D H Yu, D J Kim, T-G Lim, S K Jung, C Peng, Y-Y Cho, S Dickinson, D Alberts, G T Bowden, J Einspahr, S P Stratton, C Curiel-Lewandrowski, A M Bode, K W Lee and Z Dong, Fyn is a redox sensor involved in solar ultraviolet light-induced signal transduction in skin carcinogenesis, Oncogene, 10.1038/onc.2015.471, 35, 31, (4091-4101), (2015).

Fyn - Saito - 2010 - Cancer - Wiley Online Library

11.02.2010· J-E Kim, E Roh, M H Lee, D H Yu, D J Kim, T-G Lim, S K Jung, C Peng, Y-Y Cho, S Dickinson, D Alberts, G T Bowden, J Einspahr, S P Stratton, C Curiel-Lewandrowski, A M Bode, K W Lee and Z Dong, Fyn is a redox sensor involved in solar ultraviolet light-induced signal transduction in skin carcinogenesis, Oncogene, 10.1038/onc.2015.471, 35, 31 ...

Fyn specifically Regulates the activity of red cell ...

01.09.2020· Fyn is a redox sensor involved in solar ultraviolet light-induced signal transduction in skin carcinogenesis Oncogene , 35 ( 2016 ) , pp. 4091 - 4101 CrossRef View Record in Scopus Google Scholar

Redox regulation of tyrosine kinase signalling: more than ...

For example, Fyn and Yes represent ubiquitously expressed SFK members that also contain a CXXXXXXXMXXCW motif , and activation of Fyn in keratinocytes in response to solar UV-light exposure was found to involve oxidation of C488 (homologous to Src C487), which was thought to represent a potential redox sensing mechanism to induce protective cellular apoptosis and prevent melanoma .

Profibrotic epithelial TGF-β1 signaling involves NOX4 ...

02.03.2021· Fyn is a redox sensor involved in solar ultraviolet light-induced signal transduction in skin carcinogenesis. Oncogene 35: 4091–4101, 2016 . doi: 10.1038/onc.2015.471 . Crossref | PubMed | ISI | …

Fyn kinase is a novel modulator of erythropoietin ...

Fyn −/− mouse erythroblasts adapt to reactive oxygen species (ROS) by activating the redox‐related‐transcription‐factor Nrf2. However, since Fyn is a physiologic repressor of Nrf2, absence of Fyn resulted in persistent‐activation of Nrf2 and accumulation of nonfunctional proteins. ROS‐induced over‐activation of Jak2‐Akt‐mTOR‐pathway and repression of autophagy with ...

Redox Couple - an overview | ScienceDirect Topics

A. Heller, B. Miller, in Energy Storage, 1980 8 Summary. The exposed junction in semiconductor-redox couple solution solar cells may be subject to the processes of photocorrosion, light induced ion Solarhange, and adsorption of damaging impurities.Furthermore, surface states may prevent the attainment of high efficiencies. The problem of photocorrosion is attacked by judicious choice of the ...

Basics of ORP | Yokogawa Electric Corporation

It comes from a simple REDOX reaction between the titanium (IV) and iron (II) impurities. The REDOX reaction can be seen as: Ti 4+ + Fe 2+ → Ti 3+ + Fe 3+ However in order for the reaction to occur energy must be supplied. This is easily accomplished when ordinary white light passes thru the crystals. The reaction between the titanium and iron absorbs the red, orange and yellow light regions ...

Soil Redox Potential: Importance, Field Measurements, …

01.01.2007· There are two general classes of sensor materials for redox electrodes: (1) metals and (2) semiconductors. The most important characteristics of such material can be summarized as follows: the electrode should allow an electron transfer between the oxidized and the reduced species of a redox couple through the electrode interface, without any participation or change of the electrode surface in ...

Fingerprint Oxygen Redox Reactions in Batteries through ...

Realizing reversible reduction-oxidation (redox) reactions of lattice oxygen in batteries is a promising way to improve the energy and power density. However, conventional oxygen absorption spectroscopy fails to distinguish the critical oxygen chemistry in oxide-based battery electrodes. Therefore, high-efficiency full-range mapping of resonant inelastic X-ray scattering (mRIXS) has been ...

Electrochemical DNA sensors | Nature Biotechnology

01.10.2003· Electrochemistry-based sensors offer sensitivity, selectivity and low cost for the detection of selected DNA sequences or mutated genes associated with human disease. DNA-based electrochemical ...

Redox regulation of tyrosine kinase signalling: more than ...

For example, Fyn and Yes represent ubiquitously expressed SFK members that also contain a CXXXXXXXMXXCW motif , and activation of Fyn in keratinocytes in response to solar UV-light exposure was found to involve oxidation of C488 (homologous to Src C487), which was thought to represent a potential redox sensing mechanism to induce protective cellular apoptosis and prevent melanoma .

Fyn kinase is a novel modulator of erythropoietin ...

Fyn −/− mouse erythroblasts adapt to reactive oxygen species (ROS) by activating the redox‐related‐transcription‐factor Nrf2. However, since Fyn is a physiologic repressor of Nrf2, absence of Fyn resulted in persistent‐activation of Nrf2 and accumulation of nonfunctional proteins. ROS‐induced over‐activation of Jak2‐Akt‐mTOR‐pathway and repression of autophagy with ...

Redox Couple - an overview | ScienceDirect Topics

A. Heller, B. Miller, in Energy Storage, 1980 8 Summary. The exposed junction in semiconductor-redox couple solution solar cells may be subject to the processes of photocorrosion, light induced ion Solarhange, and adsorption of damaging impurities.Furthermore, surface states may prevent the attainment of high efficiencies. The problem of photocorrosion is attacked by judicious choice of the ...

Synthesizing Electrodes Into Electrochemical Sensor …

31.03.2021· A solar light simulator device with a 150 W xenon arc lamp, an air mass filter AM 1.5, and a 390–650 nm visible light filter was used for the experiments (Oriel Instruments). The device can be operated at different light intensities given by a lamp operation power of 150 and 95 W. The light intensity at 95 W corresponded to 1000 W m −2, as measured by a photodetector (CAS140CT-154 compact ...

A Two-Component Regulatory System in Transcriptional ...

12.02.2016· Hik2 is a sensor histidine kinase and its gene is found in all cyanobacteria. Hik2 is the homolog of Chloroplast Sensor Kinase (CSK), a protein involved in redox regulation of chloroplast gene expression during changes in light quality in plants and algae. Here we describe biochemical characterization of the signaling mechanism of Hik2 and its phosphotransferase activity. Results …

Redox-dependent condensation of the mycobacterial …

Here, we report that an intracellular redox-sensor, WhiB4, dynamically links genome condensation and oxidative stress response in Mtb. Disruption of WhiB4 affects the expression of genes involved in maintaining redox homeostasis, central metabolism, and respiration under oxidative stress. Notably, disulfide-linked oligomerization of WhiB4 in response to oxidative stress activates the protein's ...

Light Sensor - Circuit Diagram, Working and Its Applications

07.01.2021· Light Sensor Circuit Working Operation. The light sensor circuit is an electronic circuit designed using (light sensor) LDR, Darlington pair, relay, diode, and resistors which are connected as shown in the light sensor circuit diagram. A 230v AC supply is provided to the load (in this case, the load is represented with a lamp).

Pointing Sensors and Sun Tracking Techniques

05.05.2011· In general the Slit Sensor is applied to solar trough collectors and linear Fresnel lenses because its sensitivity is only on one axis. Solar troughs are linear collectors employed in solar plant and they are usually placed parallel to the ground. These systems are provided with a unique motor that performs the sun tracking during the whole day. The employed sensors of position should be able ...

PROCEEDINGS Open Access The role of redox mechanisms in ...

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Redox sensors and redox signalling A redox sensor is a redox-sensitive specialized protein, that is able to “sense” intracellular levels of ROS by a Figure 2 Major antioxidant defences in mammalian cells. A brief overview of antioxidant defences is offered. Antioxidant defences have been subdivided in those having as a major goal to display protection versus ROS and other oxidants (left ...

Electrochemical DNA sensors | Nature Biotechnology

01.10.2003· Electrochemistry-based sensors offer sensitivity, selectivity and low cost for the detection of selected DNA sequences or mutated genes associated with human disease. DNA-based electrochemical ...

Profibrotic epithelial TGF-β1 signaling involves NOX4 ...

02.03.2021· Fyn is a redox sensor involved in solar ultraviolet light-induced signal transduction in skin carcinogenesis. Oncogene 35: 4091–4101, 2016 . doi: 10.1038/onc.2015.471 . Crossref | PubMed | ISI | …

Redox regulation of tyrosine kinase signalling: more than ...

For example, Fyn and Yes represent ubiquitously expressed SFK members that also contain a CXXXXXXXMXXCW motif , and activation of Fyn in keratinocytes in response to solar UV-light exposure was found to involve oxidation of C488 (homologous to Src C487), which was thought to represent a potential redox sensing mechanism to induce protective cellular apoptosis and prevent melanoma .

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